Principal Scientist, Protein Characterization

Job description

We are seeking an innovative Principal Scientist to join the Protein Characterization group within Analytical Development & Quality Control (ADQC) at Alexion, AstraZeneca Rare Disease. This is an on-site role based in New Haven, CT. The successful candidate will be a scientific and technical leader. They will deliver proficiency in liquid chromatography method development, fractionation, and characterization of charge, size, and other product-related variants for biologics. This role plays a critical part in supporting biologics development throughout both clinical trials and market launch phases, including CQA assessment, forced degradation studies, and comparability evaluations. You will be responsible for: - Serve as a technical subject matter expert (SME) in LC-based protein variant characterization, including method development, optimization, fractionation, and troubleshooting! - Lead and implement fractionation studies to isolate and characterize product-related variants. - Build, develop, and apply methods for charge variant (e.g., IEX, icIEF), size variant (e.g., SEC, CE-SDS), or other product-related variant characterization of biologics. - Support and/or lead forced degra...