Doctoral Fellow: Accelerating Enzyme Evolution for Chemical Development: Intelligent Navigation of the Sequence Space - 3 year fixed term contract

Job description

Doctoral Fellow: Accelerating Enzyme Evolution for Chemical Development: Intelligent Navigation of the Sequence Space - 3 year fixed term contract Location: The Discovery Centre, Cambridge Biomedical Campus, Cambridge, UK Salary: £40,000 gross (subject to deductions in line with UK policy) plus benefit fund and bonus. Purpose of the role: A doctoral position is available for 3 years to work with AstraZeneca (Pharmaceutical Sciences, Early Chemical Development, Biocatalysis Team) and Professor Florian Hollfelder at the Biochemistry Department of Cambridge University (https://hollfelder.bioc.cam.ac.uk/). The project is part of the Horizon Europe Eu Marie Curie Network MetaExplore (www.metaexplore.eu/) and involves collaborations with various EU and UK groups on harnessing environmental sources for novel biocatalysts that may play a role in future sustainable processes with higher resource and energy efficiency. A major barrier to the wider application of biocatalysis in Pharma is the time required to optimise poor enzyme scaffolds into industrially viable biocatalysts via directed evolution. Even with state‑of‑the‑art platforms for library production, screening, and evaluation, timel...