Master's thesis in computational modelling of aerosol deposition in respiratory system
Chiesi Group · Parma, Emilia-Romagna, IT
Who we are looking for Delivering medications in and through the lungs of patients, in the form of inhaled aerosols, is a particularly challenging task as 26...
Job description
Who we are looking for Delivering medications in and through the lungs of patients, in the form of inhaled aerosols, is a particularly challenging task as 260K years of natural selection made the lungs a very good filter for particles and droplets spanning several orders of magnitude in size [1]. The complexity comes from many different factors: the self-affine (fractal) structure of the lung airways; the multi-phase nature of the air flow transporting solid particle or liquid droplets; the highly non-linear behaviour of the multi-phase flow; the multi scale nature of turbulence developing in the extra-thoracic airways (mouth/nose, throat and trachea); the size of the aerosol particles spanning a large range, from mm to nm; the physical and chemical transformation taking place in and on the transported aerosol particles as they travel into the patient lungs. Mathematical modelling and numerical simulations proved to be good tools to help the design of novel drug products for inhalation. Their development poses interesting challenging to researchers interested in classical and statistical mechanics, bio-engineering and computational sciences [2]. Besides understanding and optimizing...