Postdoctoral Scholar Research

Job description

The project focuses on the cellular and molecular mechanisms underlying early blood–brain barrier (BBB) dysfunction in multiple sclerosis (MS). Using a combination of multicellular culture configurations (endothelial cells, astrocytes, pericytes, encephalitogenic T cells, myeloid cells), molecular biology techniques, transgenic BBB-specific knockout/in, and in vivo pathophysiological analyses, the successful candidate will investigate mechanisms of BBB dysfunction in models of MS. The position will be based on 100% research effort. This position is not eligible for Visa Sponsorship - Perform molecular biology techniques, including subcloning, transformations, mutagenesis, plasmid isolations, and mammalian cell transfections. - Initiate and maintain (multicellular) cell culture, including transwell and 3D platforms. - Conduct cell culture experiments, including genetic and pharmacological manipulations. - Crossbreed and genotype transgenic mice, including general husbandry. - Perform animal surgeries and procedures, including injections, blood draws, perfusions, and tissue harvests. - Conduct animal physiology experiments, including permeability and transendothelial migration studie...