Research Associate, Process Development

Job description

Job Description: - Understands product requirements by studying and implementing oligonucleotide project objectives and targets related to engineering and chemical requirements. - Leads project development by developing synthetic routes, methods, and techniques in preparing, separating, purifying, analyzing, quantifying and resolving oligonucleotide process components and objectives. - Maintains process compliance integrity by adhering to standard operating procedures (SOP's) and current good manufacturing practices (cGMP) as appropriate. - Documents analyses by completing experiment notebooks and records; implementing process chemistry applications and analyzing results of new oligonucleotide synthesis and purification methods and processes. - Sets-up and operates laboratory equipment by following operating instructions; troubleshooting instrumentation and method issues. Applies laboratory experience in chemistry and separations to issues of process optimization, scale-up and laboratory process transfer to mid and kilo scale GMP manufacturing. - Executes Design of Experiments (DOE) and Proven Acceptable Range (PAR) experiments to support design space understanding and process vali...