Senior Principal Scientist, ADME-PK

Job description

Company Overview: Dyne Therapeutics is focused on delivering functional improvement for people living with genetically driven neuromuscular diseases. We are developing therapeutics that target muscle and the central nervous system (CNS) to address the root cause of disease. The company is advancing clinical programs for Duchenne muscular dystrophy (DMD) and myotonic dystrophy type 1 (DM1) as well as a preclinical programs for facioscapulohumeral muscular dystrophy (FSHD) and Pompe disease. At Dyne, we are on a mission to deliver functional improvement for individuals, families and communities. Learn more at https://www.dyne-tx.com/ , and follow us on X , LinkedIn and Facebook . Role Summary: The Senior Principal Scientist, ADME/PK leads preclinical PK and ADME strategy for Dyne’s drug candidates, serving as the ADME‑PK subject matter expert on discovery and program teams. This role designs and executes internal and external studies, develops translational PK and modeling approaches to support clinical dose projections, and partners cross‑functionally to advance programs from discovery through clinical development. The position authors regulatory submissions, defines science‑based A...