Specialist, Target Biology

Job description

Use human genetics and multi omics to de risk therapeutic targets and guide strategic decisions across our pipeline - bring scientific rigour and creativity to early target maturation. Your new role As Specialist, Target Biology you will be an independent individual contributor delivering end-to-end target‑specific analyses and driving methodological innovation. Reporting to the Head of Target Biology, you will lead high-impact projects to reduce translational risk and inform portfolio decisions through clear, evidence-based recommendations. Day‑to‑day your tasks will include: - Lead, design and deliver end-to-end reproducible analyses of genetic (GWAS, WES/WGS), transcriptomic, proteomic and other omics datasets from internal and external sources using in‑house tools and pipelines. - Apply advanced statistical genetics approaches (e.g. GWAS, rare variant association, Mendelian Randomisation, colocalization, variant-to-gene mapping) to elucidate target biology, generate mechanistic hypotheses, nominate biomarkers and enable patient stratification. - Integrate multi-omics, single-cell and proteomic data to infer mechanism and evaluate causal evidence for therapeutic hypotheses. - As...