Postdoc in Computational Neuroepigenomics Research (m/f/d)

Job description

About us IMB ( www.imb.de ) is a research institute on the campus of the Johannes Gutenberg University in Mainz, Germany. It is generously funded by the Boehringer Ingelheim Foundation and the state of Rhineland-Palatinate. Our research focuses on the biology of the cell nucleus and ranges from the molecular level to systems and computational approaches. Researchers at IMB are supported by strong core facilities that offer state-of-the-art services in bioinformatics, cytometry, genomics, microscopy, proteomics, and protein production. Background Human brain development is spatially and temporally tightly controlled, with sequential and precise orchestration of cellular and molecular programs. Any perturbation in these molecular programs can lead to detrimental effects. For example, mutations in genes encoding epigenetic regulators, especially the BAF chromatin remodeling complexes, are frequently causative for neurodevelopmental disorders. These manifest in brain abnormalities, intellectual disabilities, and other physical aberrations. We still hardly understand the molecular mechanisms during human brain development mediated by these regulators and how their mutations manifest int...