PhD Position Modeling Release and Redistribution of Hydrophobic drugs from Lipid Nanocarriers

Job description

A Ph.D. position in computational pharmaceutical science is available at the Department of Physics, Chemistry and Pharmacy (FKF) at the University of Southern Denmark (SDU). The project is funded by the Center for Pharmaceutical Data Science Education (CPDSE). The project aims to get a better understanding of the release and redistribution of hydrophobic drugs from lipid nanocarriers by using mathematical modelling. Numerical analysis of partial differential equations will be applied to model drug distribution and partitioning in multiphase systems using the drug’s partition coefficient as a driving force. Computational chemistry will be used to crease a library of model compounds differing in lipophilicity and to calculate their key physicochemcial properties (e.g. melting point, solubility, size, chemical potential). Finally, an existing model to describe drug release by the collision mechanism will be refined by incorporating the physicochemical properties of the drug. The project will be supplementet with some experimental work as a proof of concept. Project background: A detailed understanding of drug release characteristics is essential for the rational design of drug nanocar...