Director, Process Development

Job description

The Role Moderna is seeking a Director to lead upstream process development with a primary emphasis on E. coli-based production for recombinant enzymes and plasmids critical to Moderna’s technology platforms and pipeline programs . This leader will set technical strategy and drive execution across strain and expression strategy enablement, upstream fermentation process development, scale-up/scale-down, process characterization, and technology transfer to internal manufacturing. This role requires deep expertise in E.coli physiology and fermentation engineering, including fed-batch strategies, media/feed development, inline measurements/PAT, and oxygen transfer/respiration metrics (OUR/CER), with the ability to partner effectively across downstream purification, analytics, quality, and manufacturing to deliver robust, scalable, and compliant processes. Here’s What You’ll Do: Set strategy and lead execution: Own the host strain, expression vector /plasmid and upstream process development strategy for E. coli-expressed enzymes and plasmids Translate needs into platform process roadmaps (speed, robustness, cost, scalability, quality attributes) and ensure predictable delivery from stra...