Principal Scientist, Computational Protein Design

Job description

The Role: Moderna is seeking a candidate to support protein design for vaccines and biologics across the mRNA pipeline. This is a hands-on scientific role for an experienced designer with deep understanding of protein structure, binding interfaces, and computational design methods and workflows, and track record of producing designs that are validated in vitro and in vivo. The candidate should be motivated by solving challenging biological problems. In this position, you will serve as a design lead on multiple high-impact programs. You will work closely with experimental, immunology, and discovery teams to design antigens, binders, and antibodies for mRNA therapeutics, applying state-of-the-art deep learning and structure-based design tools in partnership with in vitro selection and screening teams. You will help to develop and operationalize protein design rules calibrated to in vivo mRNA delivery. As a Principal Scientist, you will also help shape design standards, mentor other designers, and act as a visible scientific leader in computational protein design across the organization. The Principal Scientist will work closely with and report to the Senior Director, Computational De...