Postdoctoral Associate - Martins Lab
University of Florida · Palm Beach, Queensland, AU
Classification Title: Postdoctoral Associate Classification Minimum Requirements: Ph. D. and/or MD in an appropriate scientific discipline required.
Job description
Classification Title: Postdoctoral Associate Classification Minimum Requirements: Ph.D. and/or MD in an appropriate scientific discipline required. Job Description: The Martins lab at The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology is looking for a Postdoctoral Associate. Our research program is focused on developing a “one-shot” functional cure for HIV/AIDS. To that end, we are leveraging the latest advances in gene therapy to engineer long-lived host cells to continuously produce HIV-1 IgG therapeutics in vivo at levels sufficient to prevent viral replication in the absence of antiretroviral therapy (ART). Using nonhuman primates as a preclinical model of HIV/AIDS, we have shown that a single dose of adeno-associated virus (AAV) vectors at birth can result in stable expression of a HIV-1 broadly neutralizing antibody (bNAb) in plasma for years without redosing. The systemic HIV-1 immunity achieved by this strategy could block acquisition of simian-HIV infection (SHIV) in mucosal challenge models that mimic HIV transmission through breastfeeding and sexual intercourse. Additionally, ongoing studies in our group show that AAV-vectored delivery of HI...