PhD in modeling of cell migration in complex ECMs to decode the risk for young adult skin cancer

Job description

Teaser Text The Faculty of Science, the Mathematical Institute and the Institute of Biology are looking for a PhD Student in Theoretical or Mathematical Biology (1.0 FTE) What you will do: The opening is for a research position within the field of computational science, mathematical or theoretical biology, computational physics, or applied mathematics. This PhD project is part of the EU project PhotoMel ( Decoding Early-Life UVA and Skincare Additive Interactions Driving Melanoma Risk and Progression in Young Adults ), a multidisciplinary consortium of 7 European universities and partners. Together, PhotoMel aims to prevent melanoma (skin cancer) onset in young adults by decoding the impact of chemical exposures on UVA-induced damage in early childhood, including ECM remodeling and skin cell mutations that shape the melanoma niche. Your task will be to further develop two-dimensional models of melanoma cell migration in complex 2D ECMs. The goal will be to determine how UV/chemical-induced ECM changes affect melanoma cell migration, proliferation, and gene expression. We will build upon a recent hybrid Cellular Potts model (hCPM) of cell-ECM interactions, which couples CPMs of cell...