Senior Scientist, Medicinal Chemistry Discovery

Job description

Overview Monte Rosa Therapeutics (MRT) seeks to recruit an enthusiastic, creative and highly talented medicinal chemist who is eager to discover molecular glue degraders (MGDs) that eliminate disease-causing proteins previously thought undruggable. This position plays a key role in contributing to the development of our growing portfolio and will have a crucial impact at the forefront of drug discovery. The successful candidate should have strong interest in early-stage drug discovery, prior experience in HTS data analysis, hit follow-up as well as utilizing state-of-the-art medicinal chemistry knowledge. Responsibilities: - Analyze High Throughput Screening (HTS) output with the goal of identifying promising starting points for hit generation chemistry from our growing MGD library. - Serve as a chemistry project lead against multiple early-stage projects across different disease area. - Develop hit follow up and lead generation strategy for discovery targets in collaboration with discovery scientists. - Create structure activity relationship driven hypotheses for follow-up experiments to probe target engagement in hit validation. - Provide tool compounds and contribute to target v...