Postdoc in T Cell Immunoinformatics - DTU Health Tech

Job description

The Section of Bioinformatics, DTU Health Tech is world leading within Immunoinformatics and Machine-Learning. Currently, we, together with a leading external pharma company party, are seeking a highly talented and motivated Postdoc candidate within the field of Immunoinformatics and prediction of T cell immunogenicity. HLA class II antigen presentation is fundamental to T-helper cell immunogenicity. Over the past decade, this process has been well characterized, and robust methods have been developed to predict it with high confidence. In contrast, our understanding of the principles governing T-cell immunogenicity of HLA-presented peptides remains limited. This gap significantly restricts the utility of current antigen presentation quantification tools—both in silico and experimental—hindering early immunogenicity risk assessment during protein drug development. A deeper understanding of the mechanisms driving T-cell activation would represent a paradigm shift in biologics development. However, progress is constrained by the scarcity of high-quality, well-characterized in vitro T-cell immunogenicity data. In this project, we will leverage expertise and technology in peptide T-cel...