JobMesh

Executive Director, Multimodal & Minimally Invasive Biomarkers

AstraZeneca · Waltham, Massachusetts, US

As Executive Director, Multimodal & Minimally Invasive Biomarkers you will… Define Enterprise Strategy and Drive Portfolio Impact - Establish enterprise stra...

Job description

As Executive Director, Multimodal & Minimally Invasive Biomarkers you will… Define Enterprise Strategy and Drive Portfolio Impact - Establish enterprise strategy for minimally invasive and multimodal biomarkers, with emphasis on ctDNA across tumor-naïve and tumor-informed approaches - Build decision frameworks that guide when these approaches should and should not be used, ensuring consistent application and demonstrable ROI across programs - Develop approaches that enable comparability, reuse, and learning across studies - Define and track metrics that demonstrate value: impact on decision-making, timelines, and development efficiency Enable Critical Development Decisions: Lead Multimodal Integration and Cross-Functional Collaboration - Partner with Translational Medicine to align biomarker strategies with development plans and influence key decisions: go/no-go, dose selection, and patient selection - Guide development of ctDNA monitoring strategies that assess target engagement, depth and durability of response, and emergence of resistance, contributing to molecular response endpoints that complement or extend traditional radiographic endpoints - Articulate and defend biomarker s...