JobMesh

Scientist, cDNA Display

Manifold Bio · Boston, Massachusetts, US

Manifold Bio builds AI models for protein therapeutic design, trained on proprietary experimental data generated at unprecedented scale.

Job description

Manifold Bio builds AI models for protein therapeutic design, trained on proprietary experimental data generated at unprecedented scale. Our in vivo -centric discovery platform produces millions of experimentally validated protein designs per campaign, creating the datasets that make our models possible and our approach uniquely powerful. We combine high-throughput protein engineering with computational design to create antibody-like drugs and other biologics. Our world-class team of protein engineers, biologists, and computational scientists are working together to aim the platform at therapeutic opportunities where precise targeting is the key to overcoming clinical challenges. Position: Manifold Bio is seeking a scientist to build and own a high-throughput, automated cell-free display platform for screening computationally designed protein binder libraries against hundreds of therapeutic receptor targets. This platform will be a cornerstone of Manifold's closed-loop AI-driven molecule discovery engine, generating the large-scale, high-quality binding data needed to train and improve our design models. The ideal candidate is a hands-on scientist with deep expertise in cell-free d...