JobMesh

Senior Scientist (Computational Genomics & Large-Scale Molecular Data Analysis) - Neurology

Mount Sinai Health System · US

We are seeking a highly motivated Staff Scientist to lead and support the analysis of large-scale molecular datasets in a dynamic, collaborative research env...

Job description

We are seeking a highly motivated Staff Scientist to lead and support the analysis of large-scale molecular datasets in a dynamic, collaborative research environment. This role focuses on cutting-edge functional genomics, with an emphasis on single-cell and multi-omic technologies. The Staff Scientist will drive computational analysis of high-dimensional datasets, partnering closely with a well-integrated computational-experimental team to generate biological insights from complex genomic data. The ideal candidate has deep expertise in single-cell transcriptomics and epigenomics, experience handling large-scale datasets, and strong quantitative and programming skills. Experience in machine learning and AI approaches is highly desirable. - Lead analysis of single-cell RNA-seq and multiome datasets (joint RNA/ATAC profiling) - Perform integrative analysis across modalities, including bulk RNA-seq, ATAC-seq, and DNA methylation datasets - Develop processing pipelines for novel single cell multiomic technologies - Apply statistical modeling and machine learning methods to identify cellular states, regulatory programs, and epigenetic signatures - Design and implement integrative multi-o...