Sr/Principal Scientist, Computational Chemistry

Job description

JOB SUMMARY: We are seeking a skilled and highly motivated Computational Chemist to join our Computational Sciences group at the Iambic Therapeutics headquarters in San Diego. You will be a key player in the application of advanced ligand and structure-based techniques to drive our drug discovery efforts. You will play an active role in the research teams pursuing important therapeutics across multiple indications. You will work in a cross-functional team, collaborating closely with machine learning scientists, medicinal chemists and biologists to apply cutting edge SBDD methods across hit identification, lead optimization, and candidate selection phases. This is a hands-on role, requiring technical expertise in computational chemistry, a strong interest in the application of co-folding, familiarity with the drug discovery process and a proactive drug-hunter mindset. This role is based in our San Diego Headquarters. KEY RESPONSIBILITIES: Apply a range of ligand and structure-based approaches across hit identification, hit to lead and lead optimization phases (e.g. cheminformatics, pharmacophore modeling, docking and shape-based based virtual screening, de novo molecular design, MD...