JobMesh

Postdoctoral Research Fellow - Agentic AI for Spatial Modeling of Disease Microenvironments

Pfizer · San Diego, California, US

We are seeking a highly motivated Postdoctoral Research Fellow to develop next-generation AI methods for modeling disease microenvironments using spatial omi...

Job description

We are seeking a highly motivated Postdoctoral Research Fellow to develop next-generation AI methods for modeling disease microenvironments using spatial omics, digital pathology, and language-model–based cell representations. This is a joint role spanning Oncology R&D (ORD) and Inflammation & Immunology R&D (I&I), designed to accelerate cross-portfolio discovery through integrative computational modeling of tissue architecture, immune engagement, and disease biology. The successful candidate will work on an interdisciplinary project aimed at understanding how cellular states, spatial interfaces, and tissue architecture jointly shape therapeutic response in human disease. The postdoc will help build an agentic AI platform that integrates cell-state language models, boundary-resolved spatial profiling, and digital pathology foundation models to generate interpretable, mechanistically grounded insights from multimodal tissue data. This role offers the opportunity to contribute to both oncology and immunology/inflammation research programs, with a strong emphasis on translational impact, biomarker discovery, reverse translation, and human disease stratification. Role Responsibilities:...