Protein Sciences Research Scientist
Vertex · Seattle, Washington, US
Job Description General Summary: We are seeking a motivated Scientist to join our Protein Science team. In this role, you will purify and characterize therap...
Job description
Job Description General Summary: We are seeking a motivated Scientist to join our Protein Science team. In this role, you will purify and characterize therapeutic proteins and research reagents at milligram- to gram-scale in support of early- and late-stage discovery programs. The ideal candidate will bring strong expertise in protein purification, protein analytics, and protein-protein interaction characterization, and will help advance platform capabilities through innovative approaches in analytical characterization and biologics developability assessment. Key Duties and Responsibilities: - Operate AKTA chromatography systems using UNICORN software to purify antibodies, Fc fusion proteins, and His-tagged protein reagents for in vitro and in vivo applications. - Design and execute fit-for-purpose purification strategies using Protein A, immobilized metal affinity chromatography (IMAC), ion exchange chromatography (IEX), hydrophobic interaction chromatography (HIC), and preparative size exclusion chromatography (SEC). - Perform analytical characterization using UV-Vis spectroscopy, analytical SEC on HPLC/UPLC systems with Empower software, endotoxin testing, SDS-PAGE, and western...