Translational Science Lead

Job description

The Translational Science and Early Clinical Development (TSECD) department delivers seamless, end-to-end translational evidence for our Respiratory & Immunology (R&I) portfolio: robust human target validation, development and execution of early clinical development plans with clear evidence of target engagement and pharmacology, and deeper understanding of the mechanism of action for programs in clinical development via biomarker-driven insights. The Translational Science Lead (TSL) is a key role within TSECD, accountable for the development and execution of the translational strategies for portfolio projects, underpinned by a deep understanding of disease relevant pathways and drivers. This includes human target validation plans at the time of target selection, strategies for target engagement and delivering evidence for proof-of-mechanism (PoM) in early clinical trials and deepening our understanding of the mechanism of action and patient selection during clinical development. The Translational Science Lead is a project facing role, collaborating closely with biosciences during preclinical development to support human target validation packages, and leading biomarker data explor...