Principal Scientist, Medicinal Chemistry

Job description

JOB SUMMARY: We seek an experienced and creative medicinal chemist with a proven track record of success in drug discovery. Candidates should be motivated to work in an intensely collaborative, multidisciplinary, team-based setting. The ideal candidate will be passionate about solving medicinal chemistry challenges, as well as proactively interfacing with diverse teams working on automated experimentation, AI-driven molecular generation, property predictions, and bioassay data generation. This position is on-site at our San Diego Headquarters. KEY RESPONSIBILITIES: Devise strategies to identify lead molecules and optimize them for potency, selectivity, and ADME properties using multivariant SAR analysis and hypothesis driven design principles. Execute on high quality ideas by employing a broad range of modern organic chemistry transformations, synthetic methods, creative use of parallel experimentations and implementing innovative techniques. Work closely with molecular and cellular biology, pharmacology, computational chemistry, ADME, and other key functions Influence the prospective use of computational methods and leverage automated synthesis and high-throughput experimentation...