JobMesh

Senior Research Associate, Therapeutic Discovery

Flagship Pioneering, Inc. · Cambridge, Massachusetts, US

Company Description FL121 is a privately held biotechnology company engineering nature to build next generation therapeutics.

Job description

Company Description FL121 is a privately held biotechnology company engineering nature to build next generation therapeutics. By harnessing naturally occurring chemistry and pairing it with sophisticated high-throughput screening technology, we will unlock the future of de novo drug design via curated data creation and model training. Role Overview: We are building a therapeutic discovery platform centered on biosynthetically-derived chemistry and advanced analytical readouts. This role will provide direct experimental support to the platform’s Build arm: executing cloning, expression, and purification workflows with a high degree of independence and rigor. The Sr. RA will be a hands-on contributor to day-to-day bench operations and will help maintain the throughput and data quality needed to drive rapid, data-grounded decisions. Key Responsibilities: - Execute molecular cloning workflows end-to-end using modern assembly methods (Gibson, T2S/Golden Gate, and related approaches); maintain accurate plasmid maps, sequence records, and construct libraries. - Express and purify recombinant proteins in bacterial systems; independently troubleshoot yield, solubility, and purity issues acr...