Manager/Senior Manager, IT Infrastructure and Operations

Job description

Role Overview & Key Functions: Karyopharm is seeking a Manager/Senior Manager, IT Infrastructure & Operations to serve as a senior individual contributor owning the architecture, reliability, and evolution of the company’s infrastructure environment, reporting to the VP, Information Technology. This is a hands-on role operating with a high degree of autonomy, partnering across IT, Security, and the business to design and run scalable, secure infrastructure across a mix of cloud and legacy systems in a regulated environment. This individual will lead complex initiatives end-to-end, drive modernization, and improve operational maturity across cloud and on-prem environments. Operating within a lean IT team, the role requires strong ownership, hands-on execution, and the ability to mentor others and influence infrastructure strategy without direct people management. Key Responsibilities: Technical Leadership & Execution: - Serve as the senior technical lead for infrastructure design, architecture, and operations. - Own and execute complex infrastructure initiatives end-to-end (design → build → optimize). - Act as an escalation point for critical incidents and complex system issues. - L...