Associate Research Scientist (TIRTL Collaborative Center)

Job description

The Tracking the Immune Repertoire of Tumor Lymphocytes (TIRTL) Bluesky program in the Host–Microbe Interactions Department at St. Jude supports multiple institutional research and clinical programs focused on immune repertoire profiling. Building on the foundational TIRTL seq (Pogorelyy and Kirk et al., Nature Methods 2025) method, we provide cohort scale T cell and B cell receptor (TCR and BCR) sequencing, enabling research in cancer immunology, infectious disease, and antibody discovery across the institution. We are seeking an Associate Scientist to play a key role in high-throughput immune repertoire sequencing and antibody discovery across cancer and infectious disease programs. In this position, you will perform TCR/BCR repertoire sequencing, identify tumor-infiltrating lymphocytes and, isolate and culture B cells after antigen exposure. Job description. Key Responsibilities: - Perform TCR/BCR immune repertoire sequencing by following established protocols. - Assist in developing new lab techniques as needed. - Isolate, culture, and manipulate primary immune cells (T cells, B cells, TILs). - Perform cell and molecular biology assays including flow cytometry, PCR/qPCR, ELISA....